This paper considers the initial boundary value problem for the time-space fractional delayed diffusion equation with fractional Laplacian. By using the semigroup theory of operators and the monotone iterative technique, the existence and uniqueness of mild solutions for the abstract time-space evolution equation with delay under some quasimonotone conditions are obtained. Finally, the abstract results are applied to the time-space fractional delayed diffusion equation with fractional Laplacian operator, which improve and generalize the recent results of this issue.