Abstract
Background. This study describes antimicrobial, anticancer and antioxidant properties of Sauropus androgynus stem extract. The main objective of the present study was to reveal the potential of S. androgynus strip to be used as a medicinal drug.
Materials and methods. The antimicrobial properties of S. androgynus stem extract against Aeromonas hydrophila, Escherichia coli, Edwardsiella tarda, Flavobacterium sp., Klebsiella sp., Salmonella sp., Vibrio alginolyticus, V. parahaemolyticus, V. cholerae and Pseudomonas aeruginosa were revealed by using the broth micro-dilution method, whereas the anticancer effects of the extract was determined with a colorimetric MTT (tetrazolium) assay against human breast adenocarcinoma (MCF-7). The antioxidant activity of the plant extract was characterized also by using a α, α-diphenyl-β-picrylhydrazyl (DPPH) radical scavenging method. Finally, chemical compounds of the plant extract were screened and identified by using gas chromatography – mass spectrometry (GC–MS).
Results. The minimum inhibitory concentration (MIC) values ranged from 7.81 to 62.5 mg/l in which the plant extract was found to inhibit the growth of Edwardsiella tarda, Escherichia coli, Flavobacterium sp., Pseudomonas aeruginosa and Vibrio cholerae at 7.81 mg/l, Klebsiella sp., Aeromonas hydrophila and Vibrio alginolyticus at 15.6 mg/l, and it was able to control the growth of Salmonella sp. and Vibrio parahaemolyticus at 62.5 mg/l. The results of the present study has shown S. androgynus stem extract to possess a high antimicrobial activity and a moderate antioxidant activity (inhibition concentration 50%; IC50 of DPPH is 8 ppt), but no anticancer activity. A total of 34 compounds were identified in the plant extract in which the major compounds were 9, 12, 15-octadecatrienoic acid, methyl ester, (Z, Z, Z)- (14.48%) and phytol (13.08%).
Conclusions. S. androgynus stem extract can be used as an antimicrobial and antioxidant agents.
Keywords: antimicrobial, antioxidant, anticancer, chemical compound, Sauropus androgynus stem
Downloads
Download data is not yet available.
Most read articles by the same author(s)
-
Martina RUDGALVYTĖ,
Diana STANČIŪTĖ,
Kristina BIELSKIENĖ,
Violeta JONUŠIENĖ,
Vida KIRVELIENĖ,
Kęstutis SUŽIEDĖLIS,
Vydmantas ATKOČIUS,
Konstantinas Povilas VALUCKAS,
Implementation of postgenomic technologies for cancer research. Institutional experience
,
Acta medica Lituanica: Vol. 17 No. 3-4 (2010)
-
Andrius Macas,
Diana Bilskienė,
Aleksandr Gembickij,
Ainius Žarskus,
Marius Rimaitis,
Alina Vilkė,
Ilona Šuškevičienė,
Danguolė Rugytė,
Arimantas Tamašauskas,
Multimodal neuromonitoring
,
Acta medica Lituanica: Vol. 19 No. 3 (2012)
-
Virginijus ŠAPOKA,
Vytautas KASIULEVIČIUS,
Janina DIDŽIAPETRIENĖ,
How should a clinician interpret results of randomized controlled trials?
,
Acta medica Lituanica: Vol. 17 No. 1-2 (2010)
-
Gabrielius Jakutis,
Lina Ragelienė,
Jelena Rascon,
Survival of children treated for Ewing sarcoma in Lithuania: a single centre experience
,
Acta medica Lituanica: Vol. 24 No. 4 (2017)
-
Valerijus Ostapenko,
Teresė Pipirienė Želvienė,
Giedrė Smailytė,
Andrej Ostapenko,
Raimundas Meškauskas,
Triple negative breast cancer: 5-year results of combined treatment
,
Acta medica Lituanica: Vol. 20 No. 4 (2013)
-
Evgeni Dimitrov,
Daniel Valchev,
Georgi Minkov,
Emil Enchev,
Yovcho Yovtchev,
Prediction of Poor Outcome Using the Urea to Albumin Ratio in Thoracic Empyema
,
Acta medica Lituanica: Vol. 31 No. 1 (2024): Acta medica Lituanica
-
Romanas Zykus,
Laimas Jonaitis,
Vitalija Petrenkienė,
Inga Gudinavičienė,
Limas Kupčinskas,
Combination of transient elastography with serum-based non-invasive tests improves prediction of liver fibrosis in patients with chronic hepatitis C: a prospective cohort study
,
Acta medica Lituanica: Vol. 22 No. 2 (2015)
-
Lina Grauslytė,
Gonzalo De La Cerda,
Tomas Jovaiša,
ECCO2R as a bridge to a decision in type II respiratory failure
,
Acta medica Lituanica: Vol. 26 No. 1 (2019): Acta Medica Lituanica
-
Jelena Sidorova,
Rasa Čiumbaraitė,
Džastina Čebatorienė,
Mantas Banevičius,
Rasa Liutkevičienė,
Functional acuity contrast sensitivity assessment in young and middle age healthy persons at the day time with and without glare
,
Acta medica Lituanica: Vol. 21 No. 1 (2014)
-
Virginija PALIULYTĖ,
Diana RAMAŠAUSKAITĖ,
Labour induction in postdate pregnancy: when to start – at week 40 or 41 of gestation?
,
Acta medica Lituanica: Vol. 17 No. 1-2 (2010)