Abstract
Background. This study describes antimicrobial, anticancer and antioxidant properties of Sauropus androgynus stem extract. The main objective of the present study was to reveal the potential of S. androgynus strip to be used as a medicinal drug.
Materials and methods. The antimicrobial properties of S. androgynus stem extract against Aeromonas hydrophila, Escherichia coli, Edwardsiella tarda, Flavobacterium sp., Klebsiella sp., Salmonella sp., Vibrio alginolyticus, V. parahaemolyticus, V. cholerae and Pseudomonas aeruginosa were revealed by using the broth micro-dilution method, whereas the anticancer effects of the extract was determined with a colorimetric MTT (tetrazolium) assay against human breast adenocarcinoma (MCF-7). The antioxidant activity of the plant extract was characterized also by using a α, α-diphenyl-β-picrylhydrazyl (DPPH) radical scavenging method. Finally, chemical compounds of the plant extract were screened and identified by using gas chromatography – mass spectrometry (GC–MS).
Results. The minimum inhibitory concentration (MIC) values ranged from 7.81 to 62.5 mg/l in which the plant extract was found to inhibit the growth of Edwardsiella tarda, Escherichia coli, Flavobacterium sp., Pseudomonas aeruginosa and Vibrio cholerae at 7.81 mg/l, Klebsiella sp., Aeromonas hydrophila and Vibrio alginolyticus at 15.6 mg/l, and it was able to control the growth of Salmonella sp. and Vibrio parahaemolyticus at 62.5 mg/l. The results of the present study has shown S. androgynus stem extract to possess a high antimicrobial activity and a moderate antioxidant activity (inhibition concentration 50%; IC50 of DPPH is 8 ppt), but no anticancer activity. A total of 34 compounds were identified in the plant extract in which the major compounds were 9, 12, 15-octadecatrienoic acid, methyl ester, (Z, Z, Z)- (14.48%) and phytol (13.08%).
Conclusions. S. androgynus stem extract can be used as an antimicrobial and antioxidant agents.
Keywords: antimicrobial, antioxidant, anticancer, chemical compound, Sauropus androgynus stem
Downloads
Download data is not yet available.
Most read articles by the same author(s)
-
Veselin DICKOV,
The aspect of brands and marketing development in pharmaceutical industry
,
Acta medica Lituanica: Vol. 19 No. 2 (2012)
-
Gabija Laubner,
Gabija Gintautaitė,
Robertas Badaras,
Challenges in the diagnostics and management of hydrochlorothiazide-induced severe hyponatremia in a habitual beer drinker
,
Acta medica Lituanica: Vol. 27 No. 1 (2020): Acta medica Lituanica
-
Aistis Žalnora,
Vitalija Miežutavičiūtė,
Mental hygiene movement as a (r)evolutionary trend in public health in interwar Kaunas and Vilnius from 1918 to 1939
,
Acta medica Lituanica: Vol. 23 No. 3 (2016)
-
Inna Jaremko,
Asta Mačiulienė,
Arūnas Gelmanas,
Tautvydas Baranauskas,
Ramūnas Tamošiūnas,
Alfredas Smailys,
Andrius Macas,
Can the inferior vena cava collapsibility index be useful in predicting hypotension during spinal anaesthesia in a spontaneously breathing patient? A mini fluid challenge
,
Acta medica Lituanica: Vol. 26 No. 1 (2019): Acta Medica Lituanica
-
Bünyamin Tosunoğlu,
Sultan Merve Ünal,
Seyfi Emre Aksoy,
Tahir Kurtuluş Yoldaş,
Vertigo and Ischemic Stroke after Hyperextension (Beauty Parlour Stroke syndrome)
,
Acta medica Lituanica: Vol. 29 No. 2 (2022): Acta medica Lituanica
-
Simona Bereikienė,
Jelena Rascon,
Hemofagocitinė limfohistiocitozė: literatūros apžvalga
,
Acta medica Lituanica: Vol. 24 No. 1 (2017)
-
Denisas Dankinas,
Sigita Mėlynytė,
Aldona Šiurkutė,
Kastytis Dapšys,
Response preparation and intra-individual reaction time variability in schizophrenia
,
Acta medica Lituanica: Vol. 23 No. 1 (2016)
-
Theodore Young,
Joaquim Cevallos,
James Napier,
Juan Martin-Lazaro,
Metformin poisoning treated with high dose insulin dextrose therapy: a case series
,
Acta medica Lituanica: Vol. 26 No. 1 (2019): Acta Medica Lituanica
-
Anastasija Bašarinaitė,
Aušra Bučaitė,
Eglė Kontrimavičiūtė,
Jūratė Šipylaitė,
Diana Ramašauskaitė,
Epidurinis skausmo malšinimas akušerijoje: gimdyvių savijauta, informacijos šaltiniai ir noras kito gimdymo metu keisti analgezijos būdą
,
Acta medica Lituanica: Vol. 22 No. 1 (2015)
-
Vilius Rudaitis,
Gailė Maldutytė,
Jūratė Brazauskienė,
Mykolas Pavlauskas,
Dileta Valančienė,
Caesarean Scar Pregnancy: A Case Report
,
Acta medica Lituanica: Vol. 29 No. 1 (2022): Acta medica Lituanica