Abstract
Ochratoxin A (OTA) is a naturally occurring contaminant of cereals, pigmeat, and other foods and is a known genotoxic in animals. It is a nephrotoxin and a carcinogen associated with Balkan endemic nephropathy and urinary tract tumours. It is also thought to be a cause of testicular cancer. A previous study has shown that consumption of foods contaminated with ochratoxin A during pregnancy induces lesions in testicular DNA of male offspring, and this supports a possible role for OTA in testicular cancer. Additionally, prenatal exposure to ochratoxin A in mice significantly depresses expression of the DMRT1 gene in male offspring, and the loss of this gene produces germ cell testicular tumours in mice. This molecular evidence supports the theory that ochratoxin A might be related to germ cell testicular tumours in mice and in humans.
Keywords: ochratoxin A, testicular cancer, mycotoxins
Downloads
Download data is not yet available.
Most read articles by the same author(s)
-
Paulina Tekoriutė,
Monika Matuliauskaitė,
Laimas Virginijus Jonaitis,
Drug-Induced Intersticial Nephritis. Clinical Case
,
Acta medica Lituanica: Vol. 28 No. 2 (2021): Acta medica Lituanica
-
Gerda Čėsnaitė,
Gintautas Domža,
Diana Ramašauskaitė,
Jelena Volochovič,
Diana Bužinskienė,
Factors affecting the maternal-foetal relationship
,
Acta medica Lituanica: Vol. 26 No. 2 (2019): Acta Medica Lituanica
-
Jūratė Gudaitytė,
Dominykas Dvylys,
Indrė Šimeliūnaitė,
Anaesthetic challenges in cancer patients: current therapies and pain management
,
Acta medica Lituanica: Vol. 24 No. 2 (2017)
-
Austėja Voiniušytė,
Miglė Černiauskaitė,
Virginija Paliulytė,
Rūta Einikytė,
Diana Ramašauskaitė,
Vaccination Against COVID-19 Disease During Pregnancy
,
Acta medica Lituanica: Vol. 29 No. 1 (2022): Acta medica Lituanica
-
Živilė Gudlevičienė,
Raminta Baušytė,
Evelina Dagytė,
Danutė Balkelienė,
Algirdas Utkus,
Diana Ramašauskaitė,
The First Live Birth in Lithuania After Application of Preimplantation Genetic Testing
,
Acta medica Lituanica: Vol. 27 No. 2 (2020): Acta medica Lituanica
-
Mindaugas Stankūnas,
Kersti Pärna,
Anna Tisler,
Anda Ķīvīte-Urtāne,
Una Kojalo,
Jana Zodzika,
Nicholas Baltzer,
Jan Nygard,
Mari Nygard,
Anneli Uuskula,
Cervical Cancer in the Baltic States: Can Intelligent and Personalised Cancer Screening Change the Situation?
,
Acta medica Lituanica: Vol. 29 No. 1 (2022): Acta medica Lituanica
-
Olga Rimdenoka,
Māra Pilmane,
Evaluation of TGF-β1 and EGFR in Cleft Affected Lip Mucosa
,
Acta medica Lituanica: Vol. 28 No. 1 (2021): Acta medica Lituanica
-
Kazys MILAŠIUS,
Marija PEČIUKONIENĖ,
Rūta DADELIENĖ,
Juozas SKERNEVIČIUS,
Efficacy of the Tribulus food supplement used by athletes
,
Acta medica Lituanica: Vol. 17 No. 1-2 (2010)
-
Gabrielis KUNDROTAS,
Surface markers distinguishing mesenchymal stem cells from fibroblasts
,
Acta medica Lituanica: Vol. 19 No. 2 (2012)
-
Vladislav Lisovski,
Mindaugas Minderis,
Intraneural ganglion cyst: a case report and a review of the literature
,
Acta medica Lituanica: Vol. 26 No. 2 (2019): Acta Medica Lituanica