Abstract
Background. It is important to prepare response in advance to increase the efficiency of its execution. The process of response preparation is usually studied using the precueing paradigm. In this paradigm subjects have to employ the preceding information about further imperative stimulus to perform proper response preparation, which shortens the reaction time of subsequent response execution. Previous studies detected the impairment of response preparation in schizophrenia only with the help of electroencephalographic parameters, but not with the assessing of reaction time. Therefore, in this study we attempted to find a behavioural parameter that could detect impairment in response preparation of schizophrenia patients. It was recently found that appropriate response preparation not only shortens the reaction time but also increases its stability, which is measured with the intra-individual reaction time variability. It was also revealed that response stability could better find cognitive dysfunction in some studies of schizophrenia disorder than classical behavioural parameters. Hence, the main goal of this study was to verify if intra-individual reaction time variability could detect the impairment of response preparation in schizophrenia patients.
Materials and methods. In order to achieve the main purpose, we carried out a study with 14 schizophrenia patients and 14 control group subjects. We used precueing paradigm in our research, in which participants had to employ information about stimulus probability for the proper response preparation.
Results. Our main result showed that despite the responses of schizophrenia patients were faster to the high-probability stimulus than to the low-probability one (F (1, 13) = 30.9, p < 0.001), intra-individual reaction time variability did not differ in this group between the responses to more and less probable stimuli (F (1, 13) = 0.64, p = 0.44).
Conclusions. Results of the study suggest that people with schizophrenia were able to use precueing probabilistic information only to shorten their reaction time, but not to increase response stability. Therefore, it was found that intra-individual reaction time variability parameter could detect response preparation impairment in schizophrenia, and could be used in clinical purposes.
Downloads
Download data is not yet available.
Most read articles by the same author(s)
-
Rimantas Jankauskas,
Table of Contents and Editorial Board
,
Acta medica Lituanica: Vol. 30 No. 1 (2023): Acta medica Lituanica
-
Vygantas Barsys,
Vida Garalienė,
Gediminas Urbonas,
Contraction force versus action potential duration of cardiomyocytes: which methodology is more informative for selection of effective 1,4-dihydropyridine compounds in experimental research?
,
Acta medica Lituanica: Vol. 22 No. 1 (2015)
-
Sigutė STADALNYKAITĖ,
Rūta BRIEDIENĖ,
Radiological diagnostics of triple negative breast cancer: a review
,
Acta medica Lituanica: Vol. 18 No. 2 (2011)
-
Andrius Brazaitis,
Algirdas Tamošiūnas,
Janina Tutkuvienė,
Patellofemoral joint biomechanics in the females with anterior knee pain applying full weight bearing kinematic MRI
,
Acta medica Lituanica: Vol. 22 No. 1 (2015)
-
Saulė Švedienė,
Juozas Ivaškevičius,
Good medical practice for regional block’s procedures
,
Acta medica Lituanica: Vol. 19 No. 3 (2012)
-
Saulius CICĖNAS,
Vladislavas VENCEVIČIUS,
Malignant pulmonary neoplasms predisposing to pneumothorax
,
Acta medica Lituanica: Vol. 18 No. 2 (2011)
-
Laura Lukošienė,
Lina Kalibatienė,
Vidmantas Barauskas,
Intercostal nerve block in pediatric minimally invasive thoracic surgery
,
Acta medica Lituanica: Vol. 19 No. 3 (2012)
-
Aleksandras VILIONSKIS,
Olga KNOKNERIENĖ,
Dalius JATUŽIS,
Efficacy and safety of intravenous thrombolysis for acute ischemic stroke within 3–4.5 hours in Lithuania
,
Acta medica Lituanica: Vol. 19 No. 1 (2012)
-
Ilona Savlan,
Valentina Liakina,
Jonas Valantinas,
Value of computerized inhibitory control test and blood tests in minimal hepatic encephalopathy diagnosis
,
Acta medica Lituanica: Vol. 20 No. 3 (2013)
-
Bheru Dan Charan,
Shailesh B Gaikwad,
Savyasachi Jain,
Ajay Garg,
Leve Joseph Devarajan Sebastian,
MV Padma Srivastava,
Rohit Bhatia,
Awadh Kishore Pandit,
Shashank Sarad Kale,
An Institutional Perspective on the Number of Stent Retriever Pass and Rate of Recanalization in Mechanical Thrombectomy for Acute Ischemic Stroke: When to Stop?
,
Acta medica Lituanica: Vol. 31 No. 1 (2024): Acta medica Lituanica