Abstract
Background. It is important to prepare response in advance to increase the efficiency of its execution. The process of response preparation is usually studied using the precueing paradigm. In this paradigm subjects have to employ the preceding information about further imperative stimulus to perform proper response preparation, which shortens the reaction time of subsequent response execution. Previous studies detected the impairment of response preparation in schizophrenia only with the help of electroencephalographic parameters, but not with the assessing of reaction time. Therefore, in this study we attempted to find a behavioural parameter that could detect impairment in response preparation of schizophrenia patients. It was recently found that appropriate response preparation not only shortens the reaction time but also increases its stability, which is measured with the intra-individual reaction time variability. It was also revealed that response stability could better find cognitive dysfunction in some studies of schizophrenia disorder than classical behavioural parameters. Hence, the main goal of this study was to verify if intra-individual reaction time variability could detect the impairment of response preparation in schizophrenia patients.
Materials and methods. In order to achieve the main purpose, we carried out a study with 14 schizophrenia patients and 14 control group subjects. We used precueing paradigm in our research, in which participants had to employ information about stimulus probability for the proper response preparation.
Results. Our main result showed that despite the responses of schizophrenia patients were faster to the high-probability stimulus than to the low-probability one (F (1, 13) = 30.9, p < 0.001), intra-individual reaction time variability did not differ in this group between the responses to more and less probable stimuli (F (1, 13) = 0.64, p = 0.44).
Conclusions. Results of the study suggest that people with schizophrenia were able to use precueing probabilistic information only to shorten their reaction time, but not to increase response stability. Therefore, it was found that intra-individual reaction time variability parameter could detect response preparation impairment in schizophrenia, and could be used in clinical purposes.
Downloads
Download data is not yet available.
Most read articles by the same author(s)
-
Veselin DICKOV,
The aspect of brands and marketing development in pharmaceutical industry
,
Acta medica Lituanica: Vol. 19 No. 2 (2012)
-
Gabija Laubner,
Gabija Gintautaitė,
Robertas Badaras,
Challenges in the diagnostics and management of hydrochlorothiazide-induced severe hyponatremia in a habitual beer drinker
,
Acta medica Lituanica: Vol. 27 No. 1 (2020): Acta medica Lituanica
-
Aistis Žalnora,
Vitalija Miežutavičiūtė,
Mental hygiene movement as a (r)evolutionary trend in public health in interwar Kaunas and Vilnius from 1918 to 1939
,
Acta medica Lituanica: Vol. 23 No. 3 (2016)
-
Inna Jaremko,
Asta Mačiulienė,
Arūnas Gelmanas,
Tautvydas Baranauskas,
Ramūnas Tamošiūnas,
Alfredas Smailys,
Andrius Macas,
Can the inferior vena cava collapsibility index be useful in predicting hypotension during spinal anaesthesia in a spontaneously breathing patient? A mini fluid challenge
,
Acta medica Lituanica: Vol. 26 No. 1 (2019): Acta Medica Lituanica
-
Bünyamin Tosunoğlu,
Sultan Merve Ünal,
Seyfi Emre Aksoy,
Tahir Kurtuluş Yoldaş,
Vertigo and Ischemic Stroke after Hyperextension (Beauty Parlour Stroke syndrome)
,
Acta medica Lituanica: Vol. 29 No. 2 (2022): Acta medica Lituanica
-
Simona Bereikienė,
Jelena Rascon,
Hemofagocitinė limfohistiocitozė: literatūros apžvalga
,
Acta medica Lituanica: Vol. 24 No. 1 (2017)
-
Denisas Dankinas,
Sigita Mėlynytė,
Aldona Šiurkutė,
Kastytis Dapšys,
Response preparation and intra-individual reaction time variability in schizophrenia
,
Acta medica Lituanica: Vol. 23 No. 1 (2016)
-
Theodore Young,
Joaquim Cevallos,
James Napier,
Juan Martin-Lazaro,
Metformin poisoning treated with high dose insulin dextrose therapy: a case series
,
Acta medica Lituanica: Vol. 26 No. 1 (2019): Acta Medica Lituanica
-
Anastasija Bašarinaitė,
Aušra Bučaitė,
Eglė Kontrimavičiūtė,
Jūratė Šipylaitė,
Diana Ramašauskaitė,
Epidurinis skausmo malšinimas akušerijoje: gimdyvių savijauta, informacijos šaltiniai ir noras kito gimdymo metu keisti analgezijos būdą
,
Acta medica Lituanica: Vol. 22 No. 1 (2015)
-
Vilius Rudaitis,
Gailė Maldutytė,
Jūratė Brazauskienė,
Mykolas Pavlauskas,
Dileta Valančienė,
Caesarean Scar Pregnancy: A Case Report
,
Acta medica Lituanica: Vol. 29 No. 1 (2022): Acta medica Lituanica